80mg. Usual maintenance dose is 10-20 mg once daily. Enalapril Maleate Tablets, USP is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat. Hydrochlorothiazide is a thiazide diuretic (water pill). You may have been prescribed it to reduce high blood pressure ( hypertension), or to prevent (or treat) heart failure. Response and effectiveness. The recommended Enalapril dosage for dogs is 0. Taking enalapril with other medicines. A sample config I'm using is as below:Background: We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. 1. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. Medscape - Hypertension dosing for Vaseretic (enalapril-hydrochlorothiazide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 5326/15473317-34-1-38. 4. Dogs who take enalapril should always have access to fresh water because dehydration can lead to. 5-10mg. 1 In recent years. 5 mg PO bid; target maintenance dose 20 mg/day in two divided doses. 5 mg once daily, monitor blood pressure carefully for 1–2 hours, maintenance 10–20 mg daily in 1–2 divided doses. In addition, this article aims to highlight pertinent points regarding quinapril as needed by. It has been shown that the combination of metformin and enalapril has beneficial effects, but few studies have evaluated the interactions be. Applies to: enalapril and Bactrim (sulfamethoxazole / trimethoprim) Using trimethoprim together with enalapril may increase potassium levels in the blood. are having dialysis or any other type of blood filtration. Background: Sacubitril-valsartan reduced risks of death and hospitalization for HF versus enalapril in ambulatory patients with HF and reduced. Enalapril is an inexpensive drug used alone or together with other medications to treat high blood pressure. Enalapril-Hydrochlorothiazide is a combination medication used to treat the symptoms of Hypertension ( High Blood Pressure ). The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system. It is slightly less popular than comparable drugs. 0000185. S. It works by blocking a substance in the body that causes blood vessels to tighten. The usual dose of 1. Side Effects. 31%, 3. FDA approved for use in dogs for heart failure, but is prescribed by. Objective: This prospective, randomised, open-label, blinded-endpoint study was to compare the effects of the angiotensin II (Ang II) AT1 receptor antagonist valsartan with those of the ACE inhibitor enalapril on blood pressure (BP) and cognitive functions in elderly hypertensive patients. It works by blocking a substance in the body that causes the blood vessels to tighten. Introduction. As a result, the blood vessels relax. Who can and cannot take it. One mother taking a single oral dose of enalapril 5 mg and 2 mothers taking a single dose 10 mg 3 to 45 days postpartum had undetectable enalaprilat milk levels (<0. signs of infection --fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or. Call your doctor right away if you have these signs. One mother taking a single oral dose of enalapril 5 mg and 2 mothers taking a single dose 10 mg 3 to 45 days postpartum had undetectable enalaprilat milk levels (<0. Benazepril is used to treat chronic renal-failure and proteinuria in both dogs and cats. How to use Enalapril Maleate 1 Mg/Ml Oral Solution Angiotensin Inhibiting Agents. Adult: Initially, 5 mg once daily. This medication can also be used for patients who have protein in their urine and other heart conditions. Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. Generic enalapril is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Angioten. 764 mg of enalapril. Optimal clinical application of enalapril in the treatment of hypertension and. Background: It is not known whether the treatment of patients with asymptomatic left ventricular dysfunction reduces mortality and morbidity. 7. 1. The typical initial oral dose of enalapril in. Xen support is an important part of the AMD EPYC™ processor software ecosystem. Usual dose: 20-40 mg daily. Serious side effects of enalapril include: Fainting. I’m the NetBSD developer who put some serious amount of work into the amiga port recently. e. Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2104169-CHEE-CC21ASS91Generic Name Therapeutic Classification Pharmacologic Classification bempedoic acid Cardiovascular, antihyperlipidemic ACL inhibitor benazepril CardiovascularCompare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2104155-LARA-CC21ASS87Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2104155-LARA-CC21ASS87Preventive Medicine Reducing your out-of-pocket costs for the medicine you need 2024 Advanced Control Plan – Aetna 894700-05-03 (1/24)Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2104155-LARA-CC21ASS87Libvirt List Archives. Pharmapress dosage. Brand name: Innovace. 2 mcg/L) 4 hours after a single dose. Get rid of columns 2 & 3 - rightclick on the column heading & uncheck from the list. ACE inhibitors have also been shown to improve both clinical and echocardiographic parameters in horses with mitral or aortic regurgitation. This activity outlines the indications, action, and contraindications for enalapril as a valuable agent in managing hypertension and other disorders. Davis PT Collection. Enalaprilat is poorly absorbed orally and requires intravenous administration. 2. However, head-to-head comparisons of ACEIs and calcium channel blockers (CCBs) have shown conflicting results. Signs of a high potassium level like a heartbeat that does not feel normal; change in thinking clearly and with logic; feeling weak, lightheaded, or dizzy; feel like passing out; numbness or tingling; or shortness of breath . Enalapril has an average rating of 5. Print patient leaflet as text only. The improvement in renal function is postulated to be due to the anti-hypertensive effect, the reduction in mesangial cell proliferation, and renal vasodilation, which causes a decrease in renal filtration pressure and decreased proteinuria. Aim: Both enalapril and losartan are effective and widely used in patients with chronic kidney disease (CKD). Patients taking diuretics: 0. As a result,. previo con IECA, angioedema hereditario o idiopático, 2º y 3<exp>er<exp> trimestre del embarazo. may cause a persistent cough; if it. Mitral regurgitation (MR) secondary to myxomatous degenerative mitral valve disease (DMVD) is the most common heart disease and cause of heart failure in dogs (1,2). 20mg/day (HTN) 10mg/day (HF) Disclaimer: Starting doses and titration schedule depend on individual clinical scenario and are particularly important to review with renal failure that may have different starting dose recommendations*. 41 major drug interactions (180 brand and generic names); 324 moderate drug interactions (1533 brand and generic names); 30 minor drug interactions (231 brand and generic names); A total of 392 drugs are known to interact with lisinopril:Study with Quizlet and memorize flashcards containing terms like Enalapril maleate is prescribed for a hospitalized client. customerservice@petcarerx. Their names were Lukas and Liesl. Sometimes, vomiting or diarrhea may occur. ,Ltd China (Mainland)fatigue, headache, loss of taste, loss of appetite, nausea, vomiting, fainting, and. Periodic blood screening may be necessary to monitor for increased blood. 5, 5, 10 and 20 mg tablets in generic forms and under the trade name Vasotec. If you have a medical need for one of these drugs, your doctor can ask for an exception. Lisinopril: HTN: Initial 10 mg daily (no diuretic) or 5 mg daily (if on. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. Blood and urine tests may be needed to check for unwanted effects. sore throat. Enalapril is a medicine used to reduce high blood pressure and to prevent or treat heart failure. People with diabetic neuropathy are particularly susceptible to developing. Beta blockers. Week 2. Plasmahalveringstid ca. Alapren dosage. enalapril: [noun] an antihypertensive drug C20H28N2O5 that is an ACE inhibitor administered orally in the form of its maleate. La combinación de enalapril e hidroclorotiazida se usa para tratar la presión arterial alta. 37% of reviewers reported a positive effect, while 44% reported a negative effect. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Both compounds undergo renal excretion without further metabolism. Seek medical care or call 911 at once if you have the following serious side effects:Its molecular formula is C 20 H 28 N 2 O 5 C 4 H 4 O 4, and its structural formula is: Enalapril maleate is a white to off-white, crystalline powder with a molecular weight of 492. It is important to distinguish enalapril-induced cough from cough resulting from acute illness, reactive airway disease, and congestive heart failure. Common questions. Download. ACE inhibitors have also been shown to improve both clinical and echocardiographic parameters in horses with mitral or aortic regurgitation. See the full pregnancy warnings document. Concomitant diuretics; diabetes (may lower blood glucose; increased risk of hyperkalaemia); first dose hypotension (especially in patients taking high doses of diuretics, on a low-sodium diet, on dialysis, dehydrated, or with cerebrovascular disease, ischaemic heart disease, or heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. How and when to take it. These may include vomiting, diarrhea, lack of appetite, weakness, or rashes. Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Use an effective form of birth control to keep from getting pregnant. pain in the joints. The live XEN Crypto price today is $5. However, the combination had no effect on kidney function, and proteinuria persisted over the. Enalapril (Vasotec or Epaned) is a medication used to treat high blood pressure or congestive heart failure in kids. Drug Interactions: A total of 395 drugs are known to interact with enalapril: . cough, diarrhea; chest pain, dizziness, tiredness; headache, nausea; or. 08 mg/kg (up to 5 mg) once daily. Al behandling af forhøjet blodtryk har som mål at mindske risikoen for at udvikle hjerte-kar-sygdom samt tidlig invaliditet eller død. Los principales son: Reducción de la presión arterial. Libvirt List Archives. trouble sleeping. Study with Quizlet and memorize flashcards containing terms like 1-Enalapril maleate (Vasotec) is prescribed for a hospitalized client. Enalapril systemic is used in the treatment of: Alport Syndrome. 000000590867 today with a 24-hour trading volume of $5,564,730. Drug interactions with angiotensin-converting enzyme (ACE) inhibitors include: Angiotensin-II receptor blockers and aliskerin — concomitant use of two drugs affecting the renin-angiotensin system increases the risk of hyperkalaemia, hypotension, and renal impairment. Dose should be individualised according to patient profile and blood pressure response. The course emphasizes integration of previous content, critical thinking, and therapeutic relevance. ACE inhibitors work by causing the kidneys to reduce the secretion of. Physical–Chemical Properties. . 5 mg orally once a day. Aqumeldi belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Enalapril has an average rating of 5. La combinación de enalapril e hidroclorotiazida se usa para tratar la presión arterial alta. Save 43%. Animals: Thirty-nine client-owned dogs with. However, the vet may recommend a slightly different dosage based on the underlying cause. This study aimed to longit. Lynbrook, NY 11563. Pharmacodynamics. Uses. If blood pressure is abnormal, it should then be measured on alternate days until it normalizes. by Xen. If a patient is receiving diuretic. Collapse the Reports List, select the tiny < arrow - to increase the Report data window. Diarrhea. Enalapril is a pro-drug; following oral administration, it is. Studies on interventions that can delay or treat frailty in humans are limited. The enalapril-induced cough is insidious, dry, persistent, benign, and reversible on discontinuation of therapy. 8 Department of Pharmacology and Toxicology, Radboud Institute of Health Sciences, Radboudumc, Nijmegen, the Netherlands; Department of Intensive Care and Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands. In patients with heart failure, with or without associated renal insufficiency, symptomatic hypotension has been observed. Tesla will only deliver 10 Cybertrucks at its big event this month, executive says. Choose if you have a discount code or reward points you want to use or would like to estimate your delivery cost. 1365-2125. Try to take it at the same time every day. Forhøjet blodtryk er kun en af flere faktorer, der påvirker denne risiko. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors. It is also used in the treatment of chronic kidney disease. EPANED is an angiotensin-converting enzyme (ACE) inhibitor indicated for: Treatment of hypertension in adults and children older than 1 month, to lower blood pressure. How They Work. Some side effects may occur that usually do not need medical attention. The aim of this study was to determine the effect of losartan, an antagonist of the angiotensin II type 1 receptor (AT1 receptor), and enalapril, an inhibitor of angiotensin I-converting enzyme (ACE), on viral antigen expression and IL-1β production in peritoneal. F. Optimal clinical application of enalapril in the treatment of hypertension and. The effect on systolic blood pre. . Add the remainder of the Ora-Sweet SF diluent and shake well for an additional 30 seconds. 8% on captopril and in 26. 28 Equivalent to Lisinopril 10mg Captopril 25mg BID Enalapril 10mg Ramipril 2. doi: 10. Symptoms of high potassium blood level (such as muscle weakness, slow/irregular heartbeat) Signs of infection (such as fever, chills, persistent sore throat) Changes in the amount of urine. Although the exact mechanism of its action is. Quinapril and other ACE inhibitors may also cause kidney failure and increased levels of potassium in the blood. Enalapril is a dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration). When the blood vessels open up, your blood pressure will be lowered. Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2204122-HUGO-CC22ASS20Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2204122-HUGO-CC22ASS20Mint Free XEN. a change in the way that foods taste. Follow their code on GitHub. Concomitant diuretics; diabetes (may lower blood glucose; increased risk of hyperkalaemia); first dose hypotension (especially in patients taking high doses of diuretics, on a low-sodium diet, on dialysis, dehydrated, or with cerebrovascular disease, ischaemic heart disease, or heart failure. Enalaprilat lowers BP within 15 to 30 minutes, but the BP response in hypertensive emergencies is unpredictable, in part because of variable degrees of plasma volume expansion. 5 or 5 mg, both given orally BID. diarrhoea or vomiting (see and 4. The medicine blocks ACE from forming the hormone angiotensin II, which is involved in raising blood pressure. high blood potassium --nausea, weakness, tingly. 5Sections 4. Adult: As enalaprilat: 1. Captopril. vomiting. 40mg. R J MacFadyen , P A Meredith H L Elliott. Sleep problems (insomnia) Dry mouth. Enalapril and Hydrochlorothiazide Dosage and Administration. 2 ng/mL [14] after a dose of 10 mg. It may be given to you for other reasons. Squibb Institute for Medical Research, Princeton, NJ 08540-0130. Amiloride. This is reflected by both hemodynamic (decreased blood pressure) and humoral (increased. $ 328. PROPIEDADES FARMACÉUTICAS. If your pet has difficulty taking one type of this medication, talk to one of the vets at CVCA to see what other forms may be possible. The dose for treating heart failure is 2. It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these. losartan. Maximum daily dose is 40 mg. 26% of reviewers reported a positive effect, while 56% reported a negative effect. 2. CHRONIC heart failure is a syndrome characterized by left ventricular dysfunction, reduced exercise tolerance, impaired quality of life, and markedly shortened life expectancy. Frailty is defined as an increased vulnerability to stressors, and can be considered a measure of variability in the health and risk status of people of the same chronological age (). Swelling of the lips, tongue, throat, face, hands, feet or ankles. Enalapril: HFrEF/HTN: 2. com. The usual oral dose for treating high blood pressure is 2. Maximum dose: 40 mg orally per day in 2 divided doses. miller and his wife had a son and daughter who were grown and overdue to be wed. Xen Project 4. Diabetic Kidney Disease. Angiotensin-converting-enzyme (ACE) inhibitor is the name used to describe a group of medications used to treat high blood pressure. With gratitude for the past and excitement for the future, we extend our deepest thanks to everyone who has contributed to this incredible legacy. $30 retail. Detecting differences in the effect of two antihypertensive agents is bedevilled by the inherent variability of blood pressure itself. 9% on captopril, and 20. Heart failure is a condition where your heart does not work as well as it should. Take a look at the GitHub profile guide . They are all pro-drugs administered by oral ro. There are few studies comparing equivalent doses of ACE-inhibitors, for specific indications. Nursing Considerations. You can take enalapril with or without food. Xenapril has 40 books on Goodreads, and is currently reading Catching Caroline by Sylvia Day, Persuasion by Jane Austen, and Falling in Between by Devon. Doses above 0. [2] For heart. Use of cilazapril in New Zealand is still very high. tb02601. The overall results of this study . 1 Enalapril maleate is a prodrug which when administered orally is hydrolysed to release the active converting enzyme inhibitor enalaprilat. Three trials comparing enalapril with perindopril in 116 patients with systolic heart failure were identified. Combination of nonhypotensive doses of valsartan and enalapril markedly improved survival (+87%) compared with untreated animals (37%) in spontaneously hypertensive rats (SHRs) with endothelial dysfunction. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor. The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of enalapril maleate, a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor, are reviewed. [4]Depois de sofrer esterificação. Enalapril and breastfeeding. 5 mg intervals. Who can and cannot take it. Study Design. Story by Insider • 1d. Enalapril and hydrochlorothiazide are effective treatments for hypertension. Enalapril is not suitable for everyone. Amlodipine has an average rating of 4. The most serious but very rare side effects are liver failure and angioedema (swelling of lips and throat). 1365-2125. These may include vomiting, diarrhea, lack of appetite, weakness, or rashes. 5-5 mg once or twice daily, increased up to 40 mg/day every 1-2 weeks in 2. nausea. Amlodipine is a long-lasting calcium channel blocker and Enalapril is an ACE inhibitor. Use of sacubitril/valsartan (when compared with en. low blood pressure. Hypertension: Initially 5 mg once daily if used alone or 2. 40mg/day. Enalapril differs from captopril in several respects. Quinapril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. Enalapril is an angiotensin converting enzyme (ACE; kininase II) inhibitor. Multi-ingredient medications may also be listed when applicable. 25 mg per pound of body weight given once per day. A pediatric population is a heterogeneous group with developmental differences in physiology, pathology, and biochemistry from birth until adolescence (). Follow the directions on the drug label or as provided by your veterinarian. 5mg. Possible gastrointestinal side effects include: Vomiting. 25 mg per pound once a day. 25 mg/dose every 6 hours. This lowers blood pressure and increases the supply of blood and oxygen to the heart. 18e-7 USD with a 24-hour trading volume of $2,993,614 USD. The average reduction in mean DBP was 16. Reducción de la proteinuria (pérdida de proteínas en la orina). In the pathogenesis of CHF, the proteolytic enzyme renin is released. 5 mg once a day titrated upward until blood pressure is controlled up to a maximum of 40 mg orally daily in single or 2 divided doses. Administration with food does not affect the bioavailability. Pregnancy, breastfeeding and fertility. Symptoms of high potassium blood level (such as muscle weakness, slow/irregular heartbeat) Signs of infection (such as fever, chills, persistent sore throat) Changes in the amount of urine. git repo. The laboratory results did not change appreciably and there were no. Adult: As enalaprilat: 1. Their names were Lukas and Liesl. Bottom Line. It may also be used to prevent further damage after a heart attack. 25 mg q 6 hr; monitor patient response. Please select a region / state! Postcode must be between 2 and 10 characters! Buying Lisinopril online. It is used for the treatment of hypertension, congestive heart failure, post-myocardial infarction, and other indications Hutchison and Shahan (2003). org 11september , 2014 995 100 mm Hg at screening or 95 mm Hg at random - ization, an estimated glomerular filtration rate Enalapril is an inactive drug that is metabolized to the active metabolite enalaprilat. Objective: To assess the safety profile of angiotensin-converting enzyme inhibitor therapy in infants with single ventricle. The usual dosage of enalapril for dogs is 0. skin rash. 12 (95% confidence interval [CI]: 0. Try to take it at the same time every day. This activity reviews the indications, mechanism of action, administration, adverse events, contraindications, monitoring, and toxicity of quinapril. 5mg, 5mg, 10mg, and 20mg), oral liquids, and injectable solutions. Diuretic use and advanced age increase the risk of renal impairment. Mar Vista Animal Medical Center 3850 Grand View Blvd. The orally active angiotensin-converting inhibitors (ACE inhibitors) such as captopril and enalapril represent a significant therapeutic advance in the treatment of hypertension and congestive heart failure. com. Initial dose: 2. The text only version may be available in large print, Braille or audio CD . desvanecimiento. El enalapril pertenece a una clase de medicamentos llamados inhibidores de la enzima convertidora de la angiotensina (ACE, por sus siglas en inglés). Amlodipine and Enalapril generic is prescribed for hypertension in some types of chronic heart failure. you look paler than usual, feel tired, faint or dizzy, have signs of bleeding (like bleeding from the gums or bruising more. The best ACE inhibitor for you depends on why you’re taking it, your medical history, and other factors. Alternatively, you can get the source in the following way: With a recent enough git (>= 1. ramifications. aturdimiento. counseling points. Learn about side effects, warnings, dosage, and more. Este efecto surge 1 a 2 semanas luego de haber comenzado el uso de enalapril y puede prolongarse hasta 6 meses. The most common cause of postpartum hypertension is high blood pressure (from gestational hypertension or pre-eclampsia) that persists after delivery. It also can be used in conjunction with other medications to treat mild to severe heart failure. MAIL. 3. The current CoinMarketCap ranking is #2247, with a live market cap of not available. Ramipril. Enalapril. 5 h after ingestion in healthy adult volunteers and are between 54. 00000947. One of the core features that differentiates Xen from other open-source hypervisors is its native support for stealthy and secure monitoring of guest internals (aka. In previous studies, enalapril improved survival in such patients. Insufficient evidence is available to definitively say one ACEI is superior to another and should be used preferentially, even with new meta-analyses emerging. This would allow you to use a mock testing implementation client that keeps tracks of the incoming requests that let you later run assertions on them, and returns pre-configured. conf but none of them is useful for me. In other words: you’re misunderstanding my comment. com. Eligible patients were randomized in a 1:1 fashion to sacubitril/valsartan (n = 440) or enalapril (n = 441). 5mg. With a circulating supply of 35 Trillion XEN, XEN Crypto is valued at a market cap of $20,613,761 . Benazepril oral tablet is available as a brand-name drug and a generic drug. Dosage Adjustment in Renal Impairment. com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. These targets have confluence with Daily and/or Weekly levels of resistance and/or EMA-levels. Which assessment does the nurse perform as a priority before administering the medication? Checking the client's blood pressure Checking the client's peripheral pulses Checking the most recent potassium level Checking the client's. Enalapril Orion sisältää laktoosia. Actúa disminuyendo determinadas sustancias químicas que contraen los vasos sanguíneos, de modo. Enalapril is available in tablets ([email protected] is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Enalapril itself is a weak inhibitor of ACE that is metabolically transformed to an active metabolite, enaloprilat, in. The overall results of this study . According to your prescription benefit plan, you will have toThe drugs on this list require step therapy. The purpose of this study was to re. The text only version may be available in large print, Braille or audio CD . skin rash. Enalapril (brand names: Enacard®, Vasotec®, Glioten®, Lotrial®, Pres®, Renitec®, Reniten®, Xanef®, Epaned®) is an ACE inhibitor used to treat heart failure, high blood pressure, or proteinuria (protein in the urine).